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Conan O'Brien Needs a Friend After 25 years at the Late Night desk, Conan realized that the only people rapidshwre his holiday party are the men and women who work for him. Over the years and despite Seex of interviews, Conan has never made rapidshrre real and lasting friendship with rhe of his celebrity guests. So, he started a podcast to do just that. Every week, host Alex Schmidt brings together comedians, rapieshere, scientists, and Cracked staffers, to celebrate the awesome truth that being alive is more interesting than people think it is. Significant GM atrophy of rapdshere accumbens was observed bilaterally in patients with respect to controls.
Shape analysis showed that this atrophy was located in the left medial-anterior and posterior portion of accumbens. In addition, a GM atrophy of left hypothalamus was also observed. Our results suggest that atrophy of nucleus accumbens plays an important role in psychogenic erectile dysfunction. We believe that this change can influence the motivation-related component of sexual behavior. Our findings help to elucidate a neural basis of psychogenic erectile dysfunction. Introduction Psychogenic Erectile Dysfunction ED has been defined as the persistent inability to attain and maintain an erection sufficient to permit sexual performance. Moreover, psychogenic ED represents a disorder related to psychosocial health and has a significant impact on the quality of life of both sufferers and their partners.
Epidemiological studies have shown a high prevalence and incidence of psychogenic ED among men. In the last decade, numerous functional neuroimaging studies have focused on the brain regions that are evoked by sexually relevant stimuli, showing an involvement of different cortical and subcortical structures, such as cingulate cortex, insula caudate nucleus, putamen, thalamus, amygdala and hypothalamus  — . These studies have permitted to disentangle the role played by several brain regions in different stages of visually driven sexual arousal.
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Indeed male sexual arousal has been conceived as a multidimensional experience involving cognitive, emotional and physiological components that relay on a widespread set of brain regions. Conversely, few neuroimaging studies have investigated the cerebral correlates of male sexual behavior dysfunction. These studies demonstrate that some brain regions, as, for example, the cingulate and frontal cortex, may have an inhibitory effect on the male sexual response  — . However, numerous evidences  —  indicate the importance of subcortical structures in different stages of copulative behavior.
Indeed, the hypothalamus plays a key role  in the central control of penile erection. According to Ferretti and colleagues  the hypothalamus can be brain area that triggers the erectile response evoked by erotic clips. Little is known about the role played by the remaining subcortical structures in male sexual behavior dysfunction. Among the Sex in the city movie rapidshere grey matter GM regions, the nucleus accumbens plays a well recognized role in reward and pleasure circuits  —  and the caudate nucleus in the control of the overt behavioral response of sexual arousal .
The aim of this study is to investigate if psychogenic ED patients show macro-structural alterations of deep GM structures that are involved in the male sexual response, in pleasure and reward. To test this hypothesis, structural MRI assessment of eight subcortical GM structures of the brain, such as the nucleus accumbens, amygdala, caudate, hippocampus, pallidum, putamen, thalamus and hypothalamus was performed on a study population of psychogenic ED patients and control subjects. If there are any differences between the two groups in some of these regions, our interest is to see the presence of a relationship between changes in specific brain area volumes and behavioral measures.
The study design was explained in detail and written informed consent was obtained from all participants involved in our study. Patients who visited the clinic complained of erectile dysfunction, whereas healthy subjects were recruited by means of a notice on a bulletin board at University of Chieti and Hospital of Teramo. All participants were examined according to a standardized protocol including a general medical, urologic and andrologic examination, psychiatric and psychological screening and whole brain MRI. The patients were categorized as having psychogenic erectile dysfunction generalized or situational types or organic erectile dysfunction vasculogenic, neurogenic, hormonal, metabolic, drug induced.
The Urologic assessment was performed following current guidelines for diagnosis of erectile dysfunction . The diagnostic evaluation of psychogenic erectile dysfunction Generalized type was performed by means of a physical examination with particular emphasis on the genitourinary, endocrine, vascular and neurological systems.
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Additionally, normal nocturnal and morning erections was evaluated by the Rigiscan device during three consecutive nights, while, normal penile hemodynamics mlvie assessed using color Doppler Sonography. In total, 80 patients were excluded because most of them did not meet the criteria for enrollment in the experiment. Some of them were on antidepressants, or had hormonal deficits. However, all patients with psychogenic erectile dysfunctions were enrolled. The same clinical examinations were performed on control subjects.